Chicken and Spinach Alfredo Bake Casserole with a wooden spoon in a white dish on top of a grey placemat on a white surface (with logo overlay)

Chicken and Spinach Alfredo Bake Casserole

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Combine a bunch of basic ingredients to make chicken and spinach alfredo bake with ingredients that are often found in the kitchen.

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I love creamy Alfredo sauce. Especially my homemade sauce. But it’s even better when I can use it in a variety of ways to make new favorite meals. This was a meal that we came up with during the COVID-19 pandemic. We were trying to limit visits to grocery stores which meant a lot of “pantry week” meals. 

One of those times, I was looking at all the food we had. What needed to be used first? We almost always have some chicken in the freezer. And there was baby spinach in the refrigerator that was going to go bad soon. I tend to have half-full boxes of pasta in the pantry a lot. The boys don’t eat a lot of pasta, so it leaves me with bits here and there. 

So, put all that together with some of the cheese we had and we have the ingredients for chicken and spinach alfredo! I decided it needed to be a pasta casserole to make it easier. Plus, there was a lot of it. 

Ingredients Options

Chicken

If you prefer, you can also use rotisserie chicken for this meal. Especially if you like both light and dark-meat chicken. Just make sure to pull it from the bones into bite-sized pieces. 

Alfredo Sauce

If you want a more creamy sauce, substitute heavy cream for the milk. 

​Garnish

While there’s already cheese and panko on the top of the chicken alfredo bake, there are a few things you could add. 

  • Italian seasoning
  • Red pepper flakes
  • Chopped bell peppers
  • Sour cream

Chicken and Spinach Alfredo Step by Step

Ingredients

  • 2 cups water
  • 6 oz penne pasta (uncooked)
  • 2 oz fresh spinach
  • 1 1/2 tbsp olive oil
  • 1 lb chicken breast (boneless, skinless)
  • 1 tsp onion powder
  • 1 tsp garlic powder
  • 1/4 tsp salt
  • 1/2 tsp black pepper
  • 2 cups milk
  • 2 tbsp flour
  • 1/2 cup parmesan cheese (shredded)
  • 6 green onions (chopped)
  • 1 tsp lemon zest
  • 1 tbsp lemon juice
  • 1/4 cup mozzarella cheese (shredded)
  • 1 1/2 tbsp panko

Preparation

Preheat the oven to 400F. In a large pot, bring the water to a boil and add the pasta. Cook for about 6 minutes then add the spinach.

Spinach leaves on top of boiling noodles in a large stockpot on a dark wooden surface

Cook for 2 minutes, until the spinach is wilted and the pasta is cooked al dente according to the package directions. Drain and place the al dente pasta and spinach mixture in a large bowl.

Cooked pasta noodles with wilted spinach in a stainless steel bowl on a dark wooden surface

Meanwhile, heat the oil in a large skillet over medium-high heat. Cut the chicken into bite-sized pieces and sprinkle with the onion powder, garlic powder, salt, and pepper then add to the pan. Cook for about 8 minutes, or until the chicken is cooked through and golden brown.

Bite-sized pieces of chicken cooked in a skillet on a dark wooden surface

Add the chicken to the pasta mixture.

Cooked pasta, wilted spinach, and cooked pieces of chicken in a stainless steel bowl on a dark wooden surface

Lower the heat to medium and place the green onion in the warm pan. Cook for 2 minutes.

Chopped green onion in a large skillet on a dark wooden surface

Stir in the lemon zest and juice.

Chopped green onion in lemon juice cooking in a large skillet on a dark wooden surface

Combine the milk, flour, and 1/4 cup of parmesan cheese in a bowl.

Milk, flour, and shredded cheese in a stainless steel bowl on a dark wooden surface

Add the milk mixture to the pan and bring to a boil. Cook for 2 minutes or until the sauce has thickened.

Cooked green onions in alfredo sauce boiling in a large skillet on a dark wooden surface

Add the milk mixture to the pasta mixture and toss to coat.

Cooked pasta with wilted spinach and sauce in a stainless steel bowl on a dark wooden surface

Spoon the pasta mixture into a casserole dish.

Cooked noodles, wilted spinach, and cooked chicken pieces covered with sauce in a white casserole dish on a dark wooden surface

Sprinkle with the remaining 1/4 cup of parmesan cheese, mozzarella cheese, and panko.

Cooked noodles with spinach and chicken covered with shredded cheese in a white casserole dish on a dark wooden surface

Bake for about 8-10 minutes.

Chicken and Spinach Alfredo Bake Casserole with a wooden spoon in a white dish on top of a grey placemat on a white surface (vertical)

Chicken and Spinach Alfredo Leftovers

Storage: Cover any leftover chicken alfredo pasta bake in the baking dish with aluminum foil or move to an airtight container. Refrigerate for up to 3-4 days. 

Reheating: The best way to reheat the pasta dish is to place it back in the oven for about 5-10 minutes until heated through. Or you can add a small amount of milk or cream and warm it in a saucepan over medium heat. 

Recipe

Originally Published On: September 28, 2020

Last Updated On: October 10, 2023

Chicken and Spinach Alfredo Bake Casserole with a wooden spoon in a white dish on top of a grey placemat on a white surface

Chicken and Spinach Alfredo Bake Casserole

Combine a bunch of basic ingredients to make chicken and spinach alfredo bake with ingredients that are often found in the kitchen.
Prep Time 30 minutes
Cook Time 10 minutes
Total Time 40 minutes
Course:
Main Dish
Cuisine:
American
Keyword:
alfredo sauce
|
casserole
|
chicken
|
spinach
Dietary Needs:
Egg-Free
|
Nut-Free
Meat:
Chicken/Turkey
Servings: 6 cups
5 from 17 votes

Ingredients

  • 2 cups water
  • 6 oz penne pasta (uncooked)
  • 2 oz fresh spinach
  • 1 1/2 tbsp olive oil
  • 1 lb chicken breast (boneless, skinless)
  • 1 tsp onion powder
  • 1 tsp garlic powder
  • 1/4 tsp salt
  • 1/2 tsp black pepper
  • 2 cups milk
  • 2 tbsp flour
  • 1/2 cup parmesan cheese (shredded)
  • 6 green onions (chopped)
  • 1 tsp lemon zest
  • 1 tbsp lemon juice
  • 1/4 cup mozzarella cheese (shredded)
  • 1 1/2 tbsp panko

Recommended Equipment

Instructions

  • Preheat the oven to 400F
  • In a large saucepan, bring the water to a boil and add the pasta
  • Cook for about 6 minutes then add the spinach
  • Cook for 2 minutes, until the spinach is wilted and pasta is cooked to al dente
  • Drain and place the pasta and spinach mixture in a large mixing bowl
  • Meanwhile, heat the oil in a large skillet over medium-high heat
  • Cut the chicken into bite-sized pieces and sprinkle with the onion powder, garlic powder, salt, and pepper then add to the pan
  • Cook for about 8 minutes or until the chicken is cooked through
  • Add the chicken to the pasta mixture
  • Lower the heat to medium and place the green onion in the warm pan
  • Cook for 2 minutes
  • Stir in the lemon zest and juice
  • Combine the milk, flour, and 1/4 cup of parmesan cheese in a bowl
  • Add the milk mixture to the pan and bring to a boil
  • Cook for 2 minutes or until the sauce has thickened
  • Add the milk mixture to the pasta mixture and toss to coat
  • Spoon the pasta mixture into a casserole dish and sprinkle with the remaining 1/4 cup of parmesan cheese, mozzarella cheese, and panko
  • Bake for about 8-10 minutes, until the panko starts to brown and cheese is melted
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Nutrition Facts
Chicken and Spinach Alfredo Bake Casserole
Amount Per Serving (1 cup)
Calories 345 Calories from Fat 108
% Daily Value*
Fat 12g18%
Saturated Fat 5g25%
Cholesterol 66mg22%
Sodium 416mg17%
Potassium 544mg16%
Carbohydrates 31g10%
Fiber 2g8%
Sugar 6g7%
Protein 27g54%
Vitamin A 1257IU25%
Vitamin C 7mg8%
Calcium 249mg25%
Iron 1mg6%
* Percent Daily Values are based on a 2000 calorie diet.

All nutritional information is based on third-party calculations and should be considered estimates. Actual nutrition content will vary based on brands used, measuring methods, portion sizes, and more.

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35 thoughts on “Chicken and Spinach Alfredo Bake Casserole”

  1. Neely Moldovan

    I love meals like this to take to friends who just had babies! I am totally goingto make this for our next friend who has one!

    Reply
  8. Danni Torr

    I’m a vegetarian so I tried this recipe without the chicken…it came out so delicious, even my meat-loving husband and son ate it and asked for seconds. I prepared a tossed salad as a side dish and we were good to go. We had an amazing meal!

    Reply
  10. Audrey

    5 stars
    Yummo! This is the perfect meal for my family and for me. I have five kids so anything I can make that’s easy and will feed an army is always welcome.

    Reply
  11. Ave

    5 stars
    I really like the idea of pantry week meals. It’s a really great way to use up the ingredients we have at home and stick to our food budget. This casserole is the perfect comfort food! Have to give this recipe a try soon.

    Reply
  25. Irena

    5 stars
    Simple to make and SO yummy – that’s how it looks like! Is it true? Will find out at tomorrow’s lunch time 😊 Thanks for sharing!

    Reply

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